AMG 925
AMG 925 is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
Product Specifications
CAS Number
[1401033-86-0]
UNSPSC
12352005
Target
CDK; FLT3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AMG-925.html
Purity
99.02
Solubility
DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
OCC(N1CC2=C(N=C(NC3=NC=C4C(N([C@H]5CC[C@H](C)CC5)C6=CN=CC=C64)=N3)C=C2)CC1)=O
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
References & Citations
[1]Keegan K, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014 Apr;13 (4) :880-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK6
Available Sizes
Curated Selection
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