β-Glycerophosphate (disodium salt pentahydrate)

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells[1][2][3][4].

Product Specifications

CAS Number

[13408-09-8]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; ERK; Phosphatase

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/_beta_-Glycerol_phosphate_disodium_salt_pentahydrate.html

Purity

99.99

Solubility

DMSO : < 1 mg/mL|H2O : 83.33 mg/mL (ultrasonic)

Smiles

OCC(OP(O[Na])(O[Na])=O)CO.[5H2O]

Molecular Formula

C3H17Na2O11P

Molecular Weight

306.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Belfield A, et al. Inhibition of the nucleotidase effect of alkaline phosphatase by beta-glycerophosphate. Nature. 1968 Jul 6;219 (5149) :73-5.|[2]Langenbach F, et al. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013;4 (5) :117.|[3]Chung CH, et al. Mechanism of action of beta-glycerophosphate on bone cell mineralization. Calcif Tissue Int. 1992;51 (4) :305-311.|[4]Li C, et al. Efficacy, pharmacokinetics, and biodistribution of thermosensitive chitosan/β-glycerophosphate hydrogel loaded with docetaxel. AAPS PharmSciTech. 2014 Apr;15 (2) :417-24.