P8RI

P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2].

Product Specifications

CAS Number

[2147724-76-1]

Product Name Alternative

D-P8RI

UNSPSC

12352209

Target

VEGFR

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p8ri.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL

Smiles

O=C(N1[C@H](CCC1)C(N[C@H](C)C(N[C@H](CC(C)C)C(N[C@@H](C(N[C@H](C(C)C)C(N[C@@H](C(O)=O)CCCNC(N)=N)=O)=O)CC2=CC=CC=C2)=O)=O)=O)[C@H](NC([C@H](N)CCCCN)=O)CC3=CNC4=CC=CC=C34

Molecular Formula

C51H77N13O9

Molecular Weight

1016.24

References & Citations

[1]Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42 (18) :1760-1769. |[2]Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53 (2) :746-749. |[3]Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72 (1) :45-57.