P8RI
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2].
Product Specifications
CAS Number
2147724-76-1
Product Name Alternative
D-P8RI
UNSPSC
12352209
Target
VEGFR
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p8ri.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL
Smiles
O=C(N1[C@H](CCC1)C(N[C@H](C)C(N[C@H](CC(C)C)C(N[C@@H](C(N[C@H](C(C)C)C(N[C@@H](C(O)=O)CCCNC(N)=N)=O)=O)CC2=CC=CC=C2)=O)=O)=O)[C@H](NC([C@H](N)CCCCN)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C51H77N13O9
Molecular Weight
1016.24
References & Citations
[1]Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42 (18) :1760-1769. |[2]Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53 (2) :746-749. |[3]Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72 (1) :45-57.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
OM617591 96 Strip Well
Bovine High Mobility Group AT Hook Protein 2 ELISA Kit
Sign In for Pricing
View Details 
MBS7201576-01 48 Well
Guinea pig Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) ELISA Kit
Sign In for Pricing
View Details MBS7201576-02 96 Well
Guinea pig Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) ELISA Kit
Sign In for Pricing
View Details MBS7201576-03 5x 96 Well
Guinea pig Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) ELISA Kit
Sign In for Pricing
View Details