Clonidine (hydrochloride)
Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
Product Specifications
CAS Number
4205-91-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Clonidine-hydrochloride.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl
Molecular Formula
C9H10Cl3N3
Molecular Weight
266.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19 (1) :9-15.|[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30 (9) :1746-52.|[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.|[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328 (1) :83-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
Cell Rep. 2019 Dec 3;29 (10) :2929-2935.e4|Elife. 2024 May 29.|Neurosci Bull. 2022 Apr;38 (4) :386-402.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|bioRxiv. 2025 Sep 29.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|medRxiv. 2024 May 31.
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