Clonidine (hydrochloride)

Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

Product Specifications

CAS Number

[4205-91-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Clonidine-hydrochloride.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl

Molecular Formula

C9H10Cl3N3

Molecular Weight

266.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19 (1) :9-15.|[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30 (9) :1746-52.|[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.|[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328 (1) :83-9.