NI-57

NI-57, a chemical probe, is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.

Product Specifications

CAS Number

[1883548-89-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NI-57.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(C#N)=CC=C1S(NC2=CC3=C(C=C2)N(C)C(C(C)=C3)=O)(=O)=O

Molecular Formula

C19H17N3O4S

Molecular Weight

383.42

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Igoe N, et al. Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. J Med Chem. 2017 Aug 24;60 (16) :6998-7011.