A12B4C3
Product Specifications
UNSPSC Description
A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells[1].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a12b4c3.html
Purity
98.0
Solubility
DMSO : 53 mg/mL (ultrasonic;warming)
Smiles
O=C1N(C(C2N(C(C(CCCCCCCCCC)O)C=CC12)NC3=CC=C([N+]([O-])=O)C=C3)=O)C4=CC=CC=C4
Molecular Weight
534.65
References & Citations
[1]Freschauf GK, et al. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 2009 Oct 1;69(19):7739-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100683/A12B4C3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100683/A12B4C3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1005129-80-5
Available Sizes
Curated Selection
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