Lupeol

Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) [1].

Product Specifications

CAS Number

[545-47-1]

Product Name Alternative

Clerodol; Monogynol B; Fagarasterol

UNSPSC

12352211

Hazard Statement

H302

Target

Androgen Receptor; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Lupeol.html

Purity

98.0

Solubility

DMSO : 2 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]1([C@@]2(CC[C@@]3([H])C4(C)C)C)[C@@](CC[C@]2([H])[C@]3(CC[C@@H]4O)C)([H])[C@]([C@@H]5C(C)=C)([H])[C@](C)(CC5)CC1

Molecular Formula

C30H50O

Molecular Weight

426.72

Precautions

H302

References & Citations

[1]Siddique HR, et al. Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy. Clin Cancer Res. 2011 Aug 15;17 (16) :5379-91.