Lupeol
Product Specifications
UNSPSC Description
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1].
Target Antigen
Androgen Receptor; Apoptosis
Type
Natural Products
Related Pathways
Apoptosis;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Lupeol.html
Purity
98.0
Solubility
DMSO : 2 mg/mL (ultrasonic)|Ethanol : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@]1([C@@]2(CC[C@@]3([H])C4(C)C)C)[C@@](CC[C@]2([H])[C@]3(CC[C@@H]4O)C)([H])[C@]([C@@H]5C(C)=C)([H])[C@](C)(CC5)CC1
Molecular Weight
426.72
References & Citations
[1]Siddique HR, et al. Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy. Clin Cancer Res. 2011 Aug 15;17(16):5379-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0790/Lupeol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0790/Lupeol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
545-47-1
Available Sizes
Curated Selection
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