Pristinamycin IA
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].
Product Specifications
CAS Number
[3131-03-1]
Product Name Alternative
Mikamycin B; Mikamycin IA
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Pristinamycin-IA.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H]1C(N[C@H](CC)C(N2[C@](CCC2)([H])C(N(C)[C@@H](CC3=CC=C(N(C)C)C=C3)C(N4[C@](CC(CC4)=O)([H])C(N[C@@H](C5=CC=CC=C5)C(O[C@@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O
Molecular Formula
C45H54N8O10
Molecular Weight
866.96
References & Citations
[1]Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288 (2) :187-92.|[2]Xia Cai, et al. Attenuator LRR - a regulatory tool for modulating gene expression in Gram-positive bacteria. Microb Biotechnol. 2021 Nov;14 (6) :2538-2551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide
Available Sizes
Curated Selection
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