GW274150 (phosphate)
GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM) . GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS) . GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation[1][2].
Product Specifications
CAS Number
438542-15-5
UNSPSC
12352211
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gw274150-phosphate.html
Purity
98.02
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CC(NCCSCC[C@H](N)C(O)=O)=N.O=P(O)(O)O
Molecular Formula
C8H20N3O6PS
Molecular Weight
317.30
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
INOS
Available Sizes
Frequently Asked Questions
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