KHK-IN-2
KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
Product Specifications
CAS Number
2135304-43-5
UNSPSC
12352005
Target
Ketohexokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/KHK-IN-2.html
Purity
99.05
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC1=C(C(F)(F)F)C=C(N2C[C@H](O)[C@@H](O)C2)N=C1N3CC[C@](C)(O)C3
Molecular Formula
C16H19F3N4O3
Molecular Weight
372.34
References & Citations
[1]Huard K, et al. Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK) . J Med Chem. 2017 Sep 28;60 (18) :7835-7849.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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