Hydrocinchonine

Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR) -reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp[1].

Product Specifications

CAS Number

[485-65-4]

Product Name Alternative

Dihydrocinchonine

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; P-glycoprotein

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hydrocinchonine.html

Purity

98.33

Solubility

10 mM in DMSO

Smiles

O[C@@H](C1=CC=NC2=C1C=CC=C2)[C@]3([H])[N@@](CC4)C[C@H](CC)[C@]4([H])C3

Molecular Formula

C19H24N2O

Molecular Weight

296.41

Precautions

H302

References & Citations

[1]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26 (4) :424-31.