Rimantadine-d4 (hydrochloride)

Rimantadine-d4 (hydrochloride) is the deuterium labeled Rimantadine hydrochloride. Rimantadine is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity[1].

Product Specifications

CAS Number

[350818-67-6]

UNSPSC

12352211

Hazard Statement

H301

Target

Autophagy; Influenza Virus; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.0

Solubility

10 mM in DMSO

Smiles

C(C([2H])([2H])[2H])(N)(C12CC3CC(C1)CC(C2)C3)[2H].Cl

Molecular Formula

C12H18D4ClN

Molecular Weight

219.79

Precautions

H301

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1 (2) : p. 459-78.|[3]Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80 (2) : p. 275-82.