Nirogacestat (dihydrobromide)
Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].
Product Specifications
CAS Number
1962925-29-6
Product Name Alternative
PF-3084014 (dihydrobromide) ; PF-03084014 (dihydrobromide)
UNSPSC
12352005
Target
Apoptosis; γ-secretase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nirogacestat-dihydrobromide.html
Purity
99.9
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.Br.Br
Molecular Formula
C27H43Br2F2N5O
Molecular Weight
651.47
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Available Sizes
Frequently Asked Questions
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