Z-LEVD-FMK

Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1].

Product Specifications

CAS Number

[1135688-25-3]

UNSPSC

12352005

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-levd-fmk.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)=O

Molecular Formula

C31H45FN4O10

Molecular Weight

652.71

References & Citations

[1]Bian ZM, et al. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009 Dec;50 (12) :6006-14. |[2]Ariazi EA, et al. Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A. 2011 Nov 22;108 (47) :18879-86.