F-15599

F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.

Product Specifications

CAS Number

[635323-95-4]

Product Name Alternative

NLX-101

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/F-15599.html

Purity

99.13

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCC3=NC=C(C)C=N3)(F)CC2

Molecular Formula

C19H21ClF2N4O

Molecular Weight

394.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Meadows SM, et al. Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia. Exp Neurol. 2017 Jun;292:168-178.|[2]de Boer SF, et al. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT?A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology (Berl) . 2016 Mar;233 (6) :937-47.|[3]Lladó-Pelfort L, et al. Preferential in vivo action of F15599, a novel 5-HT (1A) receptor agonist, at postsynaptic 5-HT (1A) receptors. Br J Pharmacol. 2010 Aug;160 (8) :1929-40.