MCC950
MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
Product Specifications
CAS Number
210826-40-7
Product Name Alternative
CP-456773; CRID3
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MCC950.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 9.52 mg/mL (ultrasonic; adjust pH to 10 with 1 M NaOH)
Smiles
O=S(C1=CC(C(C)(O)C)=CO1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Molecular Formula
C20H24N2O5S
Molecular Weight
404.48
Precautions
H315, H319, H320
References & Citations
[1]Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21 (3) :248-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Citation 01
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