What is the catalog number for Talfirastide?

The catalog number for Talfirastide is HY-12403.

What sizes are available for Talfirastide?

Talfirastide is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg.

How many pack sizes does Talfirastide come in?

Talfirastide is available in 5 different pack sizes.

Is Talfirastide in stock?

Talfirastide is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Talfirastide?

Talfirastide is manufactured by QuantiMol.

What is the estimated delivery time for Talfirastide?

Estimated delivery time for Talfirastide is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Talfirastide?

The safety data sheet for Talfirastide is available here: http://file.medchemexpress.com/batch_PDF/HY-12403/Talfirastide-SDS-MedChemExpress.pdf.

Talfirastide

Angiotensin 1-7 (Ang- (1-7) ) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM) . Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].

Product Specifications

CAS Number

51833-78-4

Product Name Alternative

TXA127; Angiotensin (1-7) ; Ang- (1-7)

UNSPSC

12352209

Hazard Statement

H315, H319, H335

Target

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite

Type

Peptides

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Angiotensin-1-7.html

Purity

99.91

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@@]([C@@H](C)CC)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC=N3

Molecular Formula

C41H62N12O11

Molecular Weight

899.00

Precautions

H315, H319, H335

References & Citations

[1]Gómez-Mendoza DP, et al. Angiotensin- (1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486.|[2]Li P, et al. Angiotensin- (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29 (1 Pt 2) :394-400.|[3]Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11 (3) :e0150861.|[4]Alzayadneh EM, et al. Angiotensin- (1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568 (14) 00314-3.|[5]Janatpour ZC, et al. Subcutaneous Administration of Angiotensin- (1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36 (22) :3115-3131.