Dilazep (dihydrochloride)

Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides[1][2].

Product Specifications

CAS Number

[20153-98-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Nucleoside Transporters

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dilazep-dihydrochloride.html

Concentration

10mM

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OC)=C(OC)C(OC)=C1)OCCCN2CCN(CCCOC(C3=CC(OC)=C(OC)C(OC)=C3)=O)CCC2.Cl.Cl

Molecular Formula

C31H46Cl2N2O10

Molecular Weight

677.61

Precautions

H315, H319, H335

References & Citations

[1]Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258 (3) :767-71.|[2]Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345 (4) :485-8.