Estrogen receptor β antagonist 2
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively[1].
Product Specifications
CAS Number
[2580941-14-4]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/estrogen-receptor-β-antagonist-2.html
Purity
98.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)OC2=C(C=CC(O)=C2)C1C3=CC=C(OCCN4CCOCC4)C=C3)OC
Molecular Formula
C23H26N2O6
Molecular Weight
426.46
References & Citations
[1]Carr M, et al. Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening. Bioorg Med Chem. 2020 Mar 1;28 (5) :115261.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
Available Sizes
Curated Selection
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