Thr101
Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI) .PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) [1].
Product Specifications
CAS Number
[727664-79-1]
UNSPSC
12352005
Target
Glucose-6-Phosphate Isomerase (GPI) ; Phosphomannose Isomerase (PMI)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thr101.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C
Molecular Formula
C14H10FNOS
Molecular Weight
259.30
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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