P-Cresol sulfate-d4 (potassium)
P-Cresol sulfate-d4 (potassium) is deuterium labeled p-Cresyl sulfate (potassium) . p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity[1][2][3].
Product Specifications
Product Name Alternative
P-Tolyl sulfate-d4 (potassium)
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; JNK; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
CC1=C(C([2H])=C(C([2H])=C1[2H])OS(=O)(O[K])=O)[2H]
Molecular Formula
C7H3D4KO4S
Molecular Weight
230.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tanaka H, et al, Fukagawa M. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56 (2) :347-54.|[3]Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24 (1) :88-99.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 2
Frequently Asked Questions
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