ME0328

ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM.

Product Specifications

CAS Number

[1445251-22-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ME0328.html

Purity

99.64

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C1=CC=CC=C1)C)CCC(NC2=C3C=CC=C2)=NC3=O

Molecular Formula

C19H19N3O2

Molecular Weight

321.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Lindgren AE, et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013 Aug 16;8 (8) :1698-703.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1; PARP10; PARP2; PARP3; TNKS1/PARP5A; TNKS2/PARP5B

Available Sizes

Curated Selection

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