Levofloxacin (hydrate)

Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity[1][2][3][4].

Product Specifications

CAS Number

[138199-71-0]

Product Name Alternative

Levofloxacin hemihydrate

UNSPSC

12352005

Hazard Statement

H302, H317, H334, H361, H362

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Orthopoxvirus; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Levofloxacin-hydrate.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O.[0.5H2O]

Molecular Formula

C18H20FN3O4.1/2H2O

Molecular Weight

370.38

Precautions

H302, H317, H334, H361, H362

References & Citations

[1]Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61 (3) :377-92. |[2]Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.|[3]JI B, et al. In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1995 Jun;39 (6) :1341-4.|[4]Rand A, et al. Effect of levofloxacin on some body tissues in mice. Iraqi Journal of Veterinary Sciences, 2021.