A 779
A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII.
Product Specifications
CAS Number
159432-28-7
UNSPSC
12352209
Target
Angiotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/A_779.html
Purity
99.12
Solubility
DMSO : 18.18 mg/mL (adjust pH to 2 with 1 M HCl)
Smiles
O=C(N[C@]([C@@H](C)CC)([H])C(N[C@H](C(N[C@H](C)C(O)=O)=O)CC1=CNC=N1)=O)[C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2
Molecular Formula
C39H60N12O11
Molecular Weight
872.97
References & Citations
[1]Abuohashish HM, et al. Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis. Sci Rep. 2017 May 23;7 (1) :2293.|[2]Abuohashish HM, et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed Pharmacother. 2017 Aug;92:58-68.|[3]Yan WF, et al. Effects and related mechanism of angiotensin- (1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Mar 24;45 (3) :223-229.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AT1 Receptor; AT2 Receptor
Available Sizes
Frequently Asked Questions
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