DAMGO (TFA)

DAMGO TFA is a μ-opioid receptor (μ-OPR) selective agonist with a Kd of 3.46 nM for native μ-OPR[1].

Product Specifications

CAS Number

[950492-85-0]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/damgo-tfa.html

Concentration

10mM

Purity

99.52

Solubility

H2O : ≥ 100 mg/mL

Smiles

OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1.OC(C(F)(F)F)=O

Molecular Formula

C28H36F3N5O8

Molecular Weight

627.61

References & Citations

[1]FEBS Lett. 1995 Jan 2;357 (1) :93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops.|[2]Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12 (6) :492-500.|[3] Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212 (2) :83-6.|[4]Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53 (3) :277-285.