P-nitro-Pifithrin-α
P-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].
Product Specifications
CAS Number
389850-21-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Caspase; MDM-2/p53; TGF-β Receptor
Type
Reference compound
Related Pathways
Apoptosis; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p-nitro-pifithrin-α.html
Purity
97.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br
Molecular Formula
C15H16BrN3O3S
Molecular Weight
398.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Smad2(Phospho Ser255) Rabbit Polyclonal Antibody
Smad2(Phospho Ser255) Rabbit Polyclonal Antibody
Smad2(Phospho Ser255) Rabbit Polyclonal Antibody
APC-Linked Polyclonal Antibody to Mucin 3 (MUC3)