DGAT-1 inhibitor 2

DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity[1][2].

Product Specifications

CAS Number

[942999-61-3]

UNSPSC

12352005

Target

Acyltransferase; HSP; PERK; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/DGAT-1-inhibitor-2.html

Concentration

10mM

Purity

95.70

Smiles

O=C(O)CC12CCC(CC1)(CC2)C3=CC=C(C=C3)C4=NC5=C(N)N=CN=C5OC4(C)C

Molecular Formula

C24H28N4O3

Molecular Weight

420.50

References & Citations

[1]Yang W, et al. Role of diacylglycerol O-acyltransferase (DGAT) isoforms in bovine hepatic fatty acid metabolism. J Dairy Sci. 2022 Apr;105 (4) :3588-3600.|[2]Birch AM, et al. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J Med Chem. 2009 Mar 26;52 (6) :1558-68.