CL 5343

CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 ??renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer[1][2][3].

Product Specifications

CAS Number

[14949-00-9]

Product Name Alternative

5-Amino-1,3,4-thiadiazole-2-sulfonamide

UNSPSC

12352005

Hazard Statement

H314, H318

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cl-5343.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=NN=C(N)S1)(N)=O

Molecular Formula

C2H4N4O2S2

Molecular Weight

180.21

Precautions

H314, H318

References & Citations

[1]Aday B, et al. Synthesis of novel 5-amino-1,3,4-thiadiazole-2-sulfonamide containing acridine sulfonamide/carboxamide compounds and investigation of their inhibition effects on human carbonic anhydrase I, II, IV and VII. Bioorg Chem. 2018 Apr;77:101-105.|[2]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14 (4) :689-693.|[3]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11 (8) : 2243-2264.