GW542573X
GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].
Product Specifications
CAS Number
660846-41-3
UNSPSC
12352005
Hazard Statement
H302-H319-H372-H410
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gw542573x.html
Purity
98.79
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1)OC(C)(C)C
Molecular Formula
C19H28N2O5
Molecular Weight
364.44
Precautions
P260-P264-P270-P273-P280-P305+P351+P338-P330-P391-P501
References & Citations
[1]Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4- (2-methoxyphenylcarbamoyloxymethyl) -piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76 (3) :569-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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