GW542573X

GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].

Product Specifications

CAS Number

[660846-41-3]

UNSPSC

12352005

Hazard Statement

H302-H319-H372-H410

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gw542573x.html

Purity

98.79

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1)OC(C)(C)C

Molecular Formula

C19H28N2O5

Molecular Weight

364.44

Precautions

P260-P264-P270-P273-P280-P305+P351+P338-P330-P391-P501

References & Citations

[1]Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4- (2-methoxyphenylcarbamoyloxymethyl) -piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76 (3) :569-78.