18-Oxocortisol
Product Specifications
UNSPSC Description
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].
Target Antigen
Endogenous Metabolite; Mineralocorticoid Receptor
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/18-oxocortisol.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@](C(CO)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1
Molecular Weight
376.44
References & Citations
[1]Nakamura Y, et al. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primaryaldosteronism. J Clin Endocrinol Metab. 2011 Aug;96(8):E1272-8.|[2]Ulick S, et al. 18-oxocortisol, a naturally occurring mineralocorticoid agonist. Endocrinology. 1983 Dec;113(6):2320-2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113151/18-Oxocortisol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113151/18-Oxocortisol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2410-60-8
Available Sizes
Curated Selection
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