18-Oxocortisol

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2) . 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

Product Specifications

CAS Number

[2410-60-8]

UNSPSC

12352211

Target

Endogenous Metabolite; Mineralocorticoid Receptor

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/18-oxocortisol.html

Purity

99.05

Solubility

10 mM in DMSO

Smiles

O=C1CC[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@](C(CO)=O)(O)CC[C@@]4([H])[C@]3([H])CCC2=C1

Molecular Formula

C21H28O6

Molecular Weight

376.44

References & Citations

[1]Nakamura Y, et al. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primaryaldosteronism. J Clin Endocrinol Metab. 2011 Aug;96 (8) :E1272-8.|[2]Ulick S, et al. 18-oxocortisol, a naturally occurring mineralocorticoid agonist. Endocrinology. 1983 Dec;113 (6) :2320-2.