Arachidonoyl Serinol

Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL) . Arachidonoyl Serinol inhibits the hydrolysis of [3H]2-oleoylglycerol and [3H]anandamide with IC50s of ～70 μM[1][2][3].

Product Specifications

CAS Number

[183718-70-9]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/arachidonoyl-serinol.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NC(CO)CO

Molecular Formula

C23H39NO3

Molecular Weight

377.56

Precautions

H225, H319

References & Citations

[1]Khanolkar AD, et, al. Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J Med Chem. 1996 Oct 25;39 (22) :4515-9.|[2]Fowler CJ, et, al. Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. Biochem Pharmacol. 2005 Apr 15;69 (8) :1241-5.|[3]Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143 (6) :774-84.