EG01377 (dihydrochloride)
Product Specifications
UNSPSC Description
EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects[1].
Target Antigen
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eg01377-dihydrochloride.html
Purity
98.98
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O.Cl.Cl
Molecular Weight
659.60
References & Citations
[1]Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61(9):4135-4154.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112151A/EG01377-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112151A/EG01377-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2749438-61-5
Available Sizes
Curated Selection
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