EG01377 (dihydrochloride)
EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects[1].
Product Specifications
CAS Number
[2749438-61-5]
UNSPSC
12352005
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eg01377-dihydrochloride.html
Concentration
10mM
Purity
98.98
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C2=CC=C(CN)C=C2)=CC3=C1OCC3)(NC4=C(C(N[C@@H](CCC/N=C(N)/N)C(O)=O)=O)SC=C4)=O.Cl.Cl
Molecular Formula
C26H32Cl2N6O6S2
Molecular Weight
659.60
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Virol. 2025 Oct 29:e0138425.|Cancers (Basel) . 2023 Apr 10;15 (8) :2225.|Cell Death Dis. 2023 Feb 25;14 (2) :159.
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