Envafolimab
Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC50 value of 5.25 nM. Envafolimab has the potential for the research of solid tumors[1][2][3].
Product Specifications
CAS Number
2102192-68-5
Product Name Alternative
ASC 22; KN 035
UNSPSC
12352203
Target
PD-1/PD-L1
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/envafolimab.html
Purity
99.77
Solubility
H2O
Smiles
[Envafolimab]
Molecular Weight
(80 kDa)
References & Citations
[1]Papadopoulos KP, et al. First-in-Human Phase I Study of Envafolimab, a Novel Subcutaneous Single-Domain Anti-PD-L1 Antibody, in Patients with Advanced Solid Tumors. Oncologist. 2021 Sep;26 (9) :e1514-e1525.|[2]Akinleye A, et al. Immune checkpoint inhibitors of PD-L1 as cancer therapeutics. J Hematol Oncol. 2019 Sep 5;12 (1) :92.|[3]Zhang F, Wei H, Wang X, Bai Y, Wang P, Wu J, Jiang X, Wang Y, Cai H, Xu T, Zhou A. Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Cell Discov. 2017 Mar 7;3:17004.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1258072-01 0.02 mg (E-Coli)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details MBS1258072-02 0.1 mg (E-Coli)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details MBS1258072-03 0.02 mg (Yeast)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details MBS1258072-04 0.1 mg (Yeast)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details MBS1258072-05 0.02 mg (Baculovirus)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details MBS1258072-06 0.02 mg (Mammalian-Cell)
Recombinant Pseudomonas aeruginosa Leucyl/phenylalanyl-tRNA--protein transferase (aat)
Sign In for Pricing
View Details