LY2409881
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
Product Specifications
CAS Number
946518-61-2
UNSPSC
12352005
Hazard Statement
H302
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY2409881.html
Solubility
DMSO : ≥ 37 mg/mL
Smiles
O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5
Molecular Formula
C24H29ClN6OS
Molecular Weight
485.04
Precautions
P264-P270-P330-P501
References & Citations
[1]Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21 (1) :134-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β
Citation 01
Int J Mol Sci. 2022 Dec 24;24 (1) :320.|Cell Rep. 2024 Oct 8;43 (10) :114827.|Clin Transl Med. 2022 Jun;12 (6) :e850.
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