SN38-COOH

SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs) . SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis[1][2].

Product Specifications

CAS Number

[2170118-23-5]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sn38-cooh.html

Purity

96.10

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CCC(O[C@]1(C2=C(COC1=O)C(N3C(C(C(C3)=C(C4=C5)CC)=NC4=CC=C5O)=C2)=O)CC)=O)=O

Molecular Formula

C26H24N2O8

Molecular Weight

492.48

References & Citations

[1]Wilson Lim, et al. Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. PLoS Negl Trop Dis. 2018 Apr 26;12 (4) :e0006437.|[2]Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19 (6) :1493-8.