Guanfu base H
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].
Product Specifications
CAS Number
4758-99-0
Product Name Alternative
Atisinium (chloride)
UNSPSC
12352005
Target
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/guanfu-base-h.html
Purity
99.80
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@]23[C@](C[C@@](CC3)([H])C1=C)([H])[C@]45[C@]([C@](C[N+](CCO)=C4)(CCC5)C)([H])CC2.[Cl-]
Molecular Formula
C22H34ClNO2
Molecular Weight
379.96
References & Citations
[1]WU Qiong, et al. Simultaneous Determination of Guanfu Base A, Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum (Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35 (5), 230-233.|[2]Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130 (3) :559-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium
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