Guanfu base H

Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].

Product Specifications

CAS Number

[4758-99-0]

Product Name Alternative

Atisinium (chloride)

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/guanfu-base-h.html

Purity

99.80

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@]23[C@](C[C@@](CC3)([H])C1=C)([H])[C@]45[C@]([C@](C[N+](CCO)=C4)(CCC5)C)([H])CC2.[Cl-]

Molecular Formula

C22H34ClNO2

Molecular Weight

379.96

References & Citations

[1]WU Qiong, et al. Simultaneous Determination of Guanfu Base A, Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum (Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35 (5), 230-233.|[2]Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130 (3) :559-62.