BD-9136

BD-9136 is a potent and highly selective BRD4 PROTAC depressant. BD-9136 has low-nanomolar degradation potencies against BRD4 , and its degradation selectivity for BRD4 is 1000 times that of BRD2 and BRD3 proteins. BD-9136 has antitumor activity[1]. (Pink: Desmethyl-QCA276 (HY-44103) ; Black: 3- (2- (4-Methylpiperazin-1-yl) ethyl) azetidin-3-ol; Blue: Thalidomide-4-OH (HY-103596) )

Product Specifications

CAS Number

[3037514-38-5]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bd-9136.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(S4)C#CC5=CN(N=C5)C6(CCN7CCN(CC7)C)CN(C8=C(C9=CC=C8)C(N(C9=O)C%10CCC(NC%10=O)=O)=O)C6)=C4N21

Molecular Formula

C44H44N10O5S

Molecular Weight

824.95

References & Citations

[1]Hu J, et al. Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity. J Med Chem. 2023 Jun 22;66 (12) :8222-8237.