Anti-Hu CD70 APC

*Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T: The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4 (+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int Immunol. 2009 Aug;21 (8) :891-904., URL: http://www.ncbi.nlm.nih.gov/pubmed/19556308 Kaufma, *Israel BF, Pickles RJ, Segal DM, Gerard RD, Kenney SC: Enhancement of adenovirus vector entry into CD70-positive B-cell lines by using a bispecific CD70-adenovirus fiber antibody. J Virol. 2001 Jun;75 (11) :5215-21., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=israel+bf+pickles+rj , *Trebing J, El-Mesery M, Schäfer V, Weisenberger D, Siegmund D, Silence K, Wajant H. CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants. Cell Death Dis. 2014 Jan 30;5:e1035., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=trebing+j+weisenberger+d+silence+k , *Kaufmann Y, Amariglio N, Rosenthal E, Hirsch YJ, Many A, Rechavi G: Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma. J Immunol. 2005 Nov 15;175 (10) :6940-7., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=kaufmann+y+amariglio+n

The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.