Nedisertib
Product Specifications
UNSPSC Description
Nedisertib (M3814) is a potent, orally available and selective inhibitor of DNA-PK, with an IC50 of [1][2][3].
Target Antigen
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/M3814.html
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(Cl)=C([C@@H](C2=CC=C(N=N2)OC)O)C=C1C3=NC=NC4=C3C=CC(N5CCOCC5)=C4
Molecular Weight
481.91
References & Citations
[1]L. Damstrup, et al. M3814, a DNA-dependent Protein Kinase Inhibitor (DNA-PKi), Potentiates the Effect of Ionizing Radiation (IR) in Xenotransplanted Tumors in Nude Mice. IJROBP. 2016; 94, 940-941.|[2]Frank T. Zenke, et al. Abstract 1658: M3814, a novel investigational DNA-PK inhibitor: enhancing the effect of fractionated radiotherapy leading to complete regression of tumors in mice. AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1658.|[3]Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101570/Nedisertib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101570/Nedisertib-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1637542-33-6
Available Sizes
Curated Selection
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