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CPS-11

CPS-11 (N- (Hydroxymethyl) thalidomide) a Thalidomide analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

Product Specifications

CAS Number

145945-21-7

Product Name Alternative

N- (Hydroxymethyl) thalidomide

UNSPSC

12352005

Target

NF-κB; Nuclear Factor of activated T Cells (NFAT) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cps-11.html

Purity

99.39

Smiles

O=C1N(C(C2=C1C=CC=C2)=O)C(C(N3CO)=O)CCC3=O

Molecular Formula

C14H12N2O5

Molecular Weight

288.26

References & Citations

[1]Aragon-Ching JB, et al. Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov. 2007 Jun;2 (2) :167-74. |[2]Warfel NA, et al. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res. 2006 Jun 1;12 (11 Pt 1) :3502-9.|[3]Ge Y, et al. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108 (13) :4126-35.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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