IR-1048

IR-1048 is a nitroreductase (NTR) -responsive near-infrared fluorescence (NIR) /photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment[1][2].

Product Specifications

CAS Number

[155613-98-2]

Product Name Alternative

S01448

UNSPSC

12171500

Hazard Statement

H315, H319

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ir-1048.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

[F-][B+3]([F-])([F-])[F-].ClC1=CC=C2C3=C(/C(N2CCCC)=C\C=C4C(Cl)=C(CCC\4)/C=C/C5=[N+](CCCC)C6=CC=C(Cl)C7=CC=CC5=C67)C=CC=C31

Molecular Formula

C40H38BCl3F4N2

Molecular Weight

739.91

Precautions

H315, H319

References & Citations

[1]Xiaoqing Meng, et al. Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy. Theranostics. 2018 Nov 15;8 (21) :6025-6034.|[2]Xiaoxu Kang, et al. Dual-Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor-Resident Intracellular Bacteria. Adv Mater. 2022 Dec;34 (49) :e2206765.