Pseudomonas quinolone signal

Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation[1][2][3][4].

Product Specifications

CAS Number

[108985-27-9]

Product Name Alternative

PQS

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pseudomonas-quinolone-signal.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(O)=C(CCCCCCC)NC2=C1C=CC=C2

Molecular Formula

C16H21NO2

Molecular Weight

259.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Pesci E C, et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa[J]. Proceedings of the National Academy of Sciences, 1999, 96 (20) : 11229-11234.|[2]Cooke AC, et al. Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa. mSphere. 2020 Nov 25;5 (6) :e01109-20.|[3]Lin J, et al. The Pseudomonas Quinolone Signal (PQS) : Not Just for Quorum Sensing Anymore. Front Cell Infect Microbiol. 2018 Jul 4;8:230.|[4]Bredenbruch F, et al. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ Microbiol. 2006 Aug;8 (8) :1318-29.