Aminoguanidine (hydrochloride)

Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142) . Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research[1][2][3][4].

Product Specifications

CAS Number

[1937-19-5]

Product Name Alternative

Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; NO Synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Aminoguanidine-hydrochloride.html

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

NNC(N)=N.[H]Cl

Molecular Formula

CH7ClN4

Molecular Weight

110.55

Precautions

H315, H319, H335

References & Citations

[1]Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394 (1-2) :129-35.|[2]Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47 (5) :572-580. PMID: 29066484.|[3]Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66 (3) :265-70.|[4]Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16 (1) :8-14.