PKUMDL-LC-101-D04
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7) . PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2].
Product Specifications
CAS Number
[2143896-83-5]
Product Name Alternative
GPX4-Activator-1d4
UNSPSC
12352005
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pkumdl-lc-101-d04.html
Purity
99.94
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(NC(NC2CCCC2)=S)C=C1)(NCCN)=O.[H]Cl
Molecular Formula
C14H23ClN4O2S2
Molecular Weight
378.94
References & Citations
[1]Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019;62 (1) :266-275. |[2]Yijing Yang, et al. Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative. Biomedicine & Pharmacotherapy. Volume 167, November 2023, 115547
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Curated Selection
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