Encaleret
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC50 of 12 nM. Encaleret exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1[1][2].
Product Specifications
CAS Number
[787583-71-5]
Product Name Alternative
CLTX-305; JTT-305; MK-5442
UNSPSC
12352005
Target
CaSR; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/encaleret.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 350 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C2=CC=CC=C2[C@H](OC[C@H](O)CNC(C)(C)CC3=CC=C(Cl)C(F)=C3)C)C=C1C)O
Molecular Formula
C29H33ClFNO4
Molecular Weight
514.03
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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