HA-CD44 interaction inhibitor 2

HA-CD44 interaction inhibitor 2 (compound 5) is a Hyaluronic acid (HA) -CD44 interaction inhibitor that effectively disrupts the integrity of cancer spheroids. HA-CD44 interaction inhibitor 2 also exhibits antiproliferative activity against cancer cells. HA-CD44 interaction inhibitor 2 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM[1].

Product Specifications

CAS Number

[3009761-01-4]

UNSPSC

12352005

Target

Transmembrane Glycoprotein

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-108.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=CC2=C1CCN(CC3=CC(OC)=C(OC)C(OC)=C3)C2

Molecular Formula

C19H23NO4

Molecular Weight

329.39

References & Citations

[1]Espejo-Román JM, et al. N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect. Eur J Med Chem. 2023 Oct 5;258:115570.